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KMID : 0377619970620010067
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Korean Jungang Medical Journal
1997 Volume.62 No. 1 p.67 ~ p.80
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A Study on Nutritional Status and Oral Health Status in Leukemia Patients Receiving Chemotherapy
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Abstract
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This study aimed to determine nutritional status and oral health status and obtain a basic data on the nursing intervention in reducing oral cavity complications among leukemia patients receiving chemotherapy.
Subjects were 40 institutionalized patients for leukemia in Chonnal National University Hospital, Kwang-ju City.
Data were collected with the aid of 2 structured instruments(Nutritional Assessment which were composed of biochemical study, B.W., Triceps Skin Fold(T.S.F.), & Mid-arm Muscle Circumference(M.A.M.C.) and Oral Health Assessment which were composed of objective oral cavity measure and subjective oral comfort measure) at two times, before and two weeks after the treatment from Dec. 1, 1995 to July, 30, 1996
Data were analyzed by using SAS-PC+, paired t-test, ANOVA, Pearson correlation coefficients.
The results were summarized as follows
1. Hemoglobin, hematocrit, serum albumin, total lymphocyte count, triceps muscle skin fold, and mid-arm muscle circumference were significantly lower in post-treatment scores than pre-treatment scores(p=.0001). And BUN and creatinine level were significantly higher in post-treatment scores than pre-treatment scores(p=.0001), but B.W. was not significantly changed(p=.1674).
2. The nutritional indices after two weeks chemotherapy were significantly different depending on age, sex, marital status, B.W.
Hematocrit(p=.003), serum protein(p=.053), BUN(p=.033), M.A.M.C.(p=.0015) were significantly different depending on age. Hemoglobin(p=.05), hematocrit(p=.002), BUN(p= .0001), creatinine(p=.004), T.S.F.(p=.001), and M.A.M.C.(p=.0001) were significantly higher in male than in female. M.A.M.C.(p=.0064) was significantly higher in the married than in the. unmarried. Hemoglobin(p=.02), hematocrit(p=.03), BUN(p=.02), T.S.F.(p=.0017), and M.A.M.C.(p=.0001) were significantly different depending on B.W.
3. The oral health status and comfort scores after two weeks chemotherapy were significantly lower than the scores in pre-treatment(p=.0001 ; p=.0062).
4. The oral comfort score after two weeks chemotherapy was significantly higher in male than in female(p=.0346).
5. There was a strong relationship between the oral health status and the comfort scores(r=.90).
6. There was no correlation between nutritional indices before chemotherapy and oral status score after two weeks chemotherapy.
7. There were significant relationships among nutritional indices after two weeks chemotherapy. Hemoglobin level was correlated with hematocrit(p=.001), serum protein(p=.018 9) & albumin(p=.0145) ; hematocrit was correlated with serum protein(p=.0005) & albumin (p=.0003), B.W.(p=.0101), & M.A.M.C.(p=.0003). Serum albumin was correlated with protein(p=.0001), B.W.(p=.0321), M.A.M.C.(p-.02 10) ; total lymphocyte count was correlated with T.S.F.(p=.0054) B.W. was correlated with T.S.F.(p=.004), M.A.M.C.(p=.0001), & BUN(p=.0025) ; T.S.F. was correlated with M.A.M.C.(p=.0001) ; M.A.M.C. was correlated with BUMP =.0008) ; BUN was correlated with creatinine level(p=.0003).
From the above findings, it is taken that leukemia patients receiving anti-cancer chemotherapy had the experienced of nutritional defects caused by disease and treatment. Especially nutritional status after two weeks chemotherapy was significantly poor than before chemotherapy. Therefore it is necessary to implement general nutritional assessment and support nutritional management by cancer nurses.
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